Premarin Tablets Conjugated Estrogens 0.625mg 28Tab Malaysia in Available Bangladesh

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Introduction

Premarin is a female sex hormone (estrogen). It is a part of female hormonal replacement therapy which helps in treating estrogen deficiency symptoms like hot flushes (red and warm face) and vaginal dryness. Premarin is also used to prevent osteoporosis (thinning and weakening of bone) in postmenopausal women, who are at high risk of fractures and can not take other preventive medicines for osteoporosis. It can be taken with or without food, but remember to take it at a fixed time each day for better efficacy. The dose and duration will be decided by your doctor so that you get the right amount to control your symptoms. The treatment should not be stopped abruptly without consulting your doctor as this may affect the potency of this medicine. The most common side effects of this HRT are headaches, breast pain, irregular vaginal bleeding or spotting, abdominal cramps or bloating, nausea, vomiting, and hair loss. If any of these side effects or any other symptoms which you think are because of this medicine persist for a longer duration, please inform your doctor. Before taking this medicine, it is important to tell your doctor if you are taking or have recently taken any other medicines for the same disease or other diseases. Before you initiate with this HRT, you must consult the doctor if you have a history of unexplained vaginal bleeding or if you have ever had a blood clot in your legs or your lungs. If you are pregnant or breastfeeding, you should tell your doctor before taking this medicine. Your doctor may suggest you some diagnostic or laboratory tests to know the effects and side effects of this medicine on your body.

Uses of Premarin

Hormone replacement therapy

Side effects of Premarin

Common

Bloating

Breast pain

Hair loss

Headache

Irregular vaginal bleeding

Nausea

Stomach cramp

Vomiting

Quick Tips

Premarin 0.625mg Tablet should be taken according to the recommended dosage and duration as it depends on your condition.

Take Premarin 0.625mg Tablet regularly at the same time everyday as advised.

Inform your doctor about abnormal vaginal bleeding or spotting, irregular vaginal discharge, or vaginal pain when taking Premarin 0.625mg Tablet.

Regular breast exams is advised while on Premarin 0.625mg Tablet as it may raise risk of breast cancer.

Stop taking Premarin 0.625mg Tablet and notify your doctor if you experience unexplained swelling and discomfort in your limbs, shortness of breath, chest pain, or eyesight problems. These may be signs of a blood clot in veins.

What is the menopause?

During the menopause, the production of oestrogen in a woman?s ovaries gradually stops. 

This deficiency can lead to a number of symptoms that can have a significant impact on day-to-day life, including:

Hot flushes

Depression

Sleep problems

Dryness

Osteoporosis

Stopping the menstrual cycle

Introduction of Premarin 0.625mg Tablet 28s

It may be taken with or without food, however it should be taken at the same time every day for optimal benefits. Your doctor will decide on the dose and duration so that you get the right quantity of medication to control your symptoms. The efficacy of this drug may be affected if you abruptly stop taking it without first seeing your doctor. The most common side effects are headaches, breast pain, irregular vaginal bleeding or spotting, stomach cramps or bloating, nausea, vomiting, and hair loss. If any of these side effects or any symptoms that you feel are caused by this medicine linger longer than planned, please contact your doctor. If you are now taking or have recently taken any additional drugs for the same or other diseases, you must tell your doctor. You should contact a doctor if you have a history of unexplained vaginal bleeding or have ever had a blood clot in your legs or lungs. If you are pregnant or breastfeeding, tell your doctor before using this drug. To assess the medicine's efficacy and side effects on your body, your doctor may order a variety of diagnostic or laboratory tests.

How to use Premarin

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Premarin may be taken with or without food, but it is better to take it at a fixed time.

How Premarin works

Premarin is a mixture of estrogens (female sex hormone). In women who are undergoing or have attained menopause, it prevents symptoms such as hot flushes, night sweats and mood swings. It also prevents the bones from becoming porous and fragile (osteoporosis).

How does HRT work?

Hormone Replacement Therapy eases the symptoms of menopause by supplementing the levels of hormones that the body can produce naturally. 

Premarin tablets contain conjugated oestrogens, which are natural forms of oestrogen. If you have had a hysterectomy (an operation to remove the uterus), oestrogen is the only hormone you will be required to replace.

If you have not had your uterus removed, you will be prescribed a progestogen medicine alongside Premarin. 

This is because when oestrogen levels alone are increased, the lining of the uterus (the endometrium) will grow excessively. This will substantially increase your risk of complications such as endometrial cancer. If you have not had a hysterectomy, you may instead be prescribed another medicine that provides combined HRT.

What if you forget to take Premarin?

If you miss a dose of Premarin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

You have been prescribed Premarin as a part of hormone replacement therapy to relieve symptoms of menopause.

It may also be used for preventing osteoporosis in postmenopausal women who are at high risk of fractures.

Take it at the same time everyday to help you remember to take it.

Inform your doctor if you experience any unusual vaginal bleeding or spotting, abnormal vaginal discharge or vaginal discomfort while taking Premarin.

It may increase the risk of breast cancer. Have regular breast examinations.

Stop taking this medicine and inform your doctor immediately if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, or changes in vision. These could be symptoms of a blood clot in a vein.

Brief Description

Indication

Breast cancer, Prostate cancer, Hormone replacement therapy, Oral contraceptives

Adult Dose

Menopausal Vasomotor Symptoms, Atrophic Vaginitis/Kraurosis Vulvae 0.3 mg PO once daily in either continuous daily regimen or cyclic regimen (25 days on, 5 days off); adjusted PRN; use lowest dose that control symptoms; may be given daily if medical assessment warrants it Female Hypogonadism 0.3-0.625 mg PO once daily in cyclic regimen (3 weeks on, 1 week off); may be titrated every 6-12 months; adjusted PRN; add progestin treatment should be added to maintain bone mineral density once skeletal maturity achieved Osteoporosis Prophylaxis 0.3 mg PO once daily in cyclic regimen (25 days on, 5 days off); adjusted PRN based on clinical response; may be given daily if medical assessment warrants it; administer lowest effective dose May also be used in combination with medroxyprogesterone acetate Prostate Cancer Palliation only 1.25-2.5 mg PO q8hr Abnormal Uterine Bleeding 10-20 mg/day PO divided q4hr May administer low dose medroxyprogesterone acetate with therapy or following therapy Cyclic therapy: 25 days on, 5 days off; either 3 weeks on, 1 week off Female Castration/Primary Ovarian Failure 1.25 mg PO once daily in cyclic regimen (25 days on, 5 days off); adjusted PRN; administer lowest effective dose Breast Cancer Palliation Metastatic disease in selected patients (males and females):10 mg PO q8hr for ?3 months

Contraindication

Severe liver impairment; breast carcinoma; thromboembolic disorders; CV disease; undiagnosed vag bleeding; estrogen-dependent neoplasms; hypersensitivity; pregnancy.

Mode of Action

Estrogens modulate pituitary secretion of gonadotropins, leutinising hormones and follicle-stimulating hormones through -ve feedback mechanism, thus reducing elevated levels of hormones in postmenopausal women during oestrogen replacement therapy.

Precaution

Asthma, epilepsy, migraine; heart or kidney dysfunction; CV disease; cerebrovascular disorders; diabetes, hypercalcaemia; gall bladder disease; porphyria. Childn. Lactation. Lactation: Use controversial; estrogens are excreted into breast milk in small quantities; use with caution

Side Effect

>10% Abdominal pain (15-17%),Back pain (13-14%),Breast enlargement,Breast tenderness (7-12%),Headache (26-32%),Arthralgia (7-14%),Pharyngitis (10-12%),Sinusitis (6-11%),Diarrhea (6-7%) 1-10% Depression (5-8%),Dizziness (4-6%),Nervousness (2-5%),Flatulence (6-7%),Vaginitis (5-7%),Leukorrhea (4-7%),Leg cramps (3-7%),Increased cough (4-7%),Pruritus (4-5%) Frequency Not Defined Amenorrhea,Breakthrough bleeding,Corneal curvation change,Melasma,Spotting,Vaginal moniliasis,Weight changes Potentially Fatal: Unopposed replacement therapy in postmenopausal women associated with increased risk of endometrial and breast cancer.

Pregnancy Category: X 

Lactation:

 Controversial; estrogens are excreted into breast milk in small quantities, use caution

Interaction

Rifampicin, barbiturates increase rate of metabolism. Potentially Fatal: May reduce the efficacy of anticoagulants.

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